Acamprosate in the Treatment Of Binge Eating Disorder: A placebo-controlled trial

International Journal of Eating Disorders; Volume 44, Issue 1

About the Course:

Objective: To assess preliminarily the effectiveness of acamprosate in binge eating disorder (BED).
Method: In this 10-week, randomized, placebo-controlled, flexible dose trial, 40 outpatients with BED received acamprosate (N = 20) or placebo (N=20). The primary outcome measure was binge eating episode frequency.
Results: While acamprosate was not associated with a significantly greater rate of reduction in binge eating episode frequency or any other measure in the primary longitudinal analysis, in the endpoint analysis it was associated with statistically significant improvements in binge day frequency and measures of obsessive- compulsiveness of binge eating, food craving, and quality of life. Among completers, weight and BMI decreased slightly in the acamprosate group but increased in the placebo group.
Conclusion: Although acamprosate did not separate from placebo on any outcome variable in the longitudinal analysis, results of the endpoint and completer analyses suggest the drug may have some utility in BED.

Publication Date:

January 2011

Authors

Anna L. Guerdjikova, Ph.D.; Erin L. Winstanley, Ph.D.; Anne M. O'Melia, MD; Nicole Mori, CNP; Jessica McCoy, BA; Paul E. Keck Jr., MD; James I. Hudson, MD,ScD; Susan L. McElroy, MD

About the Authors:

The authors of this journal article are a from the Lindner Center of HOPE in, Mason Ohio and the University of Cincinnati College of Medicine in Cincinnati Ohio. Additionally, contributing author James L. Hudson is from the Department of Psychiatry, Harvard Medical School and McLean Hospital in Belmont Massachusetts.

Recommended For:

This course is recommended for Counselors, Psychologists, Social Workers and other mental health professionals who seek knowledge about the pharmacotherapy of binge eating disorder (BED).

Course Objectives:

  1. Describe the rationale for testing acamprosate, a glutamate receptor modulator, in the treatment of binge eating disorder.

  2. Assess the major findings of the study.

  3. Identify the limitations of the study.

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