Methylation of the glucocorticoid receptor gene promoter in bulimic women: Associations with borderline personality disorder, suicidality and exposure to childhood abuse

Volume 46, Issue 3

About the Course:

To compare levels of methylation of the glucocorticoid receptor (GR) gene (NR3C1) promoter between women with bulimia nervosa (BN) and women with no eating disorder. Also to explore in women with BN the extent to which methylation of the GR gene promoter corresponds to childhood abuse, suicidality, or borderline personality disorder (BPD).

Journal/Publisher:

Wiley Interscience Journal, International Journal of Eating Disorders

Publication Date:

April 2013

Authors

Howard Steiger, PhD; Benoit Labonté, MSc; Patricia Groleau, BA; Gustavo Turecki MD, PhD; Mimi Israel, MD

Recommended For:

This course is recommended for health-care professionals who seek knowledge about epigenetic processes that may influence risk of developing Bulimia Nervosa and related symptomatology.

Course Objectives:

  1. Examine how DNA methylation could serve as a basic mechanism underlying the environmental regulation of gene expression, and in so doing, could influence individual psychiatric adjustment in people who are exposed to various environmental stressors.

  2. Demonstrate new findings suggesting that BN, and related borderline personality and suicidal tendencies, may be associated with increased methylation of the glucocorticoid receptor gene (i.e., a gene that is centrally involved in the modulation of individual stress reactivities)

  3. Acknowledge some of the future potentials of research involving indices of epigenetic processes.

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